Author

Shawna Miles

Fred Hutch Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:yeast· 3 Approach:experimental assay· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Antonio BedaloviD· 3 shared Alexa Usenko· 1 shared Ayush Goel· 1 shared Brandon Lofts· 1 shared Brandon R. Lofts· 1 shared Carmina Lichauco· 1 shared Dina FranićiD· 1 shared Eric Foss· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersGenetics

Antonio BedalovORCID

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3 papers

Recent·Most cited

Chromatin architecture sets origin licensing capacity

Antonio Bedalov, Eric Foss, Ilana M. Nodelman, Alexa Usenko, Holden Furutani, Ayush Goel, Brandon Lofts, Shawna Miles, Zhiguo Zhang, Gregory D. Bowman, Toshio Tsukiyama

The paper shows that chromatin architecture limits replication origin licensing capacity in budding yeast by restricting helicase loading through Isw2-dependent nucleosome repositioning.

bioRxiv · May 28, 2026 · PreprintGenetics

Sir2 and Fun30 regulate ribosomal DNA replication timing via Mcm helicase positioning and nucleosome occupancy

Carmina Lichauco, Eric J. Foss, Tonibelle N. Gatbonton-Schwager, Nelson F Athow, Brandon R. Lofts, Robin Acob, Erin L. Taylor, James J Marquez, Uyen Lao, Shawna Miles, Antonio Bedalov

This study shows that Sir2 and Fun30 regulate rDNA replication timing by controlling MCM helicase positioning and nucleosome occupancy in yeast.

eLife · Jan 20, 2025Peer-reviewedGenetics

Quiescent cells maintain active degradation-mediated protein quality control requiring proteasome, autophagy and nucleus-vacuole junctions

Dina Franić, Mihaela Pravica, Klara Zubčić, Shawna Miles, Antonio Bedalov, Mirta Boban

The paper investigates protein quality control (PQC) in quiescent yeast cells, showing that degradation pathways like proteasomes, autophagy, and nucleus-vacuole junctions are active and required for misfolded protein clearance.

Journal of Biological Chemistry · Nov 29, 2024Peer-reviewedCell Biology