Structural and biochemical insights on the mechanism of action of the clinical USP1 inhibitor, KSQ-4279
Martin Luke Rennie, Mehmet Gundogdu, Connor Arkinson, Steven Liness, Sheelagh Frame, Helen Walden
The paper investigates the mechanism of action of the USP1 inhibitor KSQ-4279 using biochemical assays and cryo-EM, showing it binds to the same site as ML323 but alters protein structure differently.
Journal of Medicinal Chemistry · Aug 27, 2024Peer-reviewedBiochemistry