Connor Arkinson

This study identifies Faf1's role in enhancing p97-mediated ubiquitin-dependent protein unfolding by stabilizing the Ufd1-Npl4 cofactor through its UBX domain.

The paper solves high-resolution structures of TXNL1 bound to the human 26S proteasome, revealing conformation-specific binding and new insights into ATP hydrolysis and substrate translocation mechanisms.

This paper identifies how Nub1 traps unfolded FAT10 for ubiquitin-independent degradation by the 26S proteasome through a novel mechanism involving structural dynamics and proteasomal engagement.

The paper investigates the mechanism of action of the USP1 inhibitor KSQ-4279 using biochemical assays and cryo-EM, showing it binds to the same site as ML323 but alters protein structure differently.

The paper introduces UBIMAX, a method to profile ubiquitylation, and identifies Dbn1 as a novel DNA damage-induced ubiquitylation target regulated by SCFβTRCP.