Author

Martin Luke Rennie

University of GlasgowORCID 0000-0002-0799-3450Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:proteomics· 2 Organism:Arabidopsis· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

Helen WaldeniD· 2 shared Abdoallah SharafiD· 1 shared Ahamed KhaniD· 1 shared Alžbeta KusováiD· 1 shared Claire JourdainiD· 1 shared Clara Ionita· 1 shared Connor ArkinsoniD· 1 shared Daniel S. P. SchubertiD· 1 shared

Activity by Year

2016-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

Helen WaldenORCID

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Author profile →

4 papers

Recent·Most cited

PWO proteins are associated with PRC2 since their emergence in vascular plants

Ahamed Khan, Saqlain Haider, Abdoallah Sharaf, Alžbeta Kusová, Jan Skalák, Claire Jourdain, Martin Luke Rennie, Petra Procházková Schrumpfová, Jan Hejátko, Daniel S. P. Schubert, Sara Farrona, Iva Mozgová

This study identifies PWO proteins as conserved interactors of PRC2 in vascular plants, showing functional conservation across species.

New Phytologist · Apr 20, 2026Peer-reviewedPlant Biology

Discovery of a FANCD2-interacting protein motif (DIP-box) linking DNA Damage Response processes

Zhenbo Cao, Giuseppina R. Briola, Clara Ionita, James Streetley, Helen Walden, Martin Luke Rennie

The paper identifies a FANCD2-interacting protein motif (DIP-box) that mediates DNA repair by recognizing linear motifs in repair proteins.

bioRxiv · Mar 25, 2026 · PreprintBiochemistry

Structural and biochemical insights on the mechanism of action of the clinical USP1 inhibitor, KSQ-4279

Martin Luke Rennie, Mehmet Gundogdu, Connor Arkinson, Steven Liness, Sheelagh Frame, Helen Walden

The paper investigates the mechanism of action of the USP1 inhibitor KSQ-4279 using biochemical assays and cryo-EM, showing it binds to the same site as ML323 but alters protein structure differently.

Journal of Medicinal Chemistry · Aug 27, 2024Peer-reviewedBiochemistry

Development and Application of Equilibrium Thermodynamic Models Describing Coupled Protein Oligomerization and Ligand Binding

Martin L. Rennie, Richard L Kingston

The paper develops equilibrium thermodynamic models to describe ligand-linked protein oligomerization, showing how Markov Chain Monte Carlo methods can quantify the coupling between ligand binding and oligomer assembly.

bioRxiv · Aug 9, 2016 · PreprintBiochemistry