Homodimerized Arpins: Binding to Arp2/3 Complexes with Positive Synergy to Inhibit Lamellipodia-Dependent Tumor Metastasis
Liru Liu, Xuejiao Zhang, Yun Zhu, Mengchen Pu, Yuru Geng, Min Wang, Rongguang Zhang, Shen Ge, Sheng Ye
This study reveals that Arpin homodimerization enhances inhibition of Arp2/3 complex-mediated actin polymerization, suppressing cancer cell migration and metastasis.
bioRxiv · Jun 24, 2025 · PreprintCancer Biology