Sequencing-free whole genome spatial transcriptomics at molecular resolution in intact tissue
Yubao Cheng, Shengyuan Dang, Yuan Zhang, Yanbo Chen, Ruihuan Yu, Liu Miao, Shengyan Jin, Ailin Han, Samuel G. Katz, Siyuan S. Wang
This paper introduces RAEFISH, a spatial transcriptomics technology that achieves whole-genome coverage and single-molecule resolution in intact tissues, enabling comprehensive analysis of RNA localization and cell interactions.
bioRxiv · Mar 6, 2025 · PreprintGenetics