Yubao Cheng

This paper introduces Epi-PHR, a non-disruptive method for single-cell spatial epigenetic profiling, revealing region-specific epigenetic profiles and allele-specific chromatin states.

The paper introduces Perturb-tracing, a high-content screening platform to identify regulators of 3D chromatin organization, discovering new factors that influence chromatin folding and nuclear architecture.

This paper introduces RAEFISH, a spatial transcriptomics technology that achieves whole-genome coverage and single-molecule resolution in intact tissues, enabling comprehensive analysis of RNA localization and cell interactions.

This study uses longitudinal single-nucleus RNA sequencing to analyze transcriptional dynamics in SCA1 cerebellum, identifying early cellular changes and applying deep learning to predict disease state.

This study uses chromatin tracing to show that single-cell domains exist on both active and inactive X chromosomes and remain stable under epigenetic perturbations.