Author

Shengyan Jin

Yale UniversityORCID 0000-0002-8667-7586Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:spatial domain detection· 2 Assay:ChIP-seq· 1

Frequent Co-Authors

Siyuan S. WangiD· 3 shared Yubao ChengiD· 3 shared Jonathan S. D. RaddaiD· 2 shared Ruihuan YuiD· 2 shared Yanbo CheniD· 2 shared Yuan ZhangiD· 2 shared Ailin Han· 1 shared Alonso TapiaiD· 1 shared

Activity by Year

2023-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersGenetics

Siyuan S. WangORCID

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4 papers

Recent·Most cited

Non-disruptive 3D profiling of combinations of epigenetic marks in single cells

Yanbo Chen, Jonathan S. D. Radda, Myles H. Alderman, Shengyan Jin, Yubao Cheng, Yuan‐Ming Zhang, Miao Liu, Andrew Xiao, Siyuan S. Wang

This paper introduces Epi-PHR, a non-disruptive method for single-cell spatial epigenetic profiling, revealing region-specific epigenetic profiles and allele-specific chromatin states.

bioRxiv · Jun 13, 2025 · PreprintGenetics

Perturb-tracing enables high-content screening of multiscale 3D genome regulators

Yubao Cheng, Mengwei Hu, Bing Yang, Tyler B Jensen, Yuan Zhang, Tianqi Yang, Ruihuan Yu, Zhaoxia Ma, Jonathan S. D. Radda, Shengyan Jin, Chongzhi Zang, Siyuan S. Wang

The paper introduces Perturb-tracing, a high-content screening platform to identify regulators of 3D chromatin organization, discovering new factors that influence chromatin folding and nuclear architecture.

Nature Methods · Apr 10, 2025Peer-reviewedGenetics

Sequencing-free whole genome spatial transcriptomics at molecular resolution in intact tissue

Yubao Cheng, Shengyuan Dang, Yuan Zhang, Yanbo Chen, Ruihuan Yu, Liu Miao, Shengyan Jin, Ailin Han, Samuel G. Katz, Siyuan S. Wang

This paper introduces RAEFISH, a spatial transcriptomics technology that achieves whole-genome coverage and single-molecule resolution in intact tissues, enabling comprehensive analysis of RNA localization and cell interactions.

bioRxiv · Mar 6, 2025 · PreprintGenetics

Regulation of Nuclear Transcription by Mitochondrial RNA

Kiran Sriram, Zhijie Qi, Dongqiang Yuan, Naseeb Kaur Malhi, Xuejing Liu, Riccardo Calandrelli, Yingjun Luo, Alonso Tapia, Shengyan Jin, Ji Shi, Martha C. Salas, Runrui Dang, Brian Armstrong, Saul J. Priceman, Ping H. Wang, , Zhen Chen

The paper identifies mitochondrial RNAs (mtRNAs) as chromatin-associated RNAs (caRNAs) that regulate nuclear transcription in response to stress and disease.

eLife · Dec 12, 2023Peer-reviewedGenomics