Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional deficits in Down Syndrome
Ashley N. Brandebura, Adrien Paumier, Quinn N. Asbell, Tao Tao, Mariel Kristine B Micael, Sherlyn Sanchez, Nicola J. Allen
This study identifies pleiotrophin dysregulation in astrocytes as a contributor to neuronal structural and functional deficits in Down Syndrome, showing potential for therapeutic intervention.
Cell Reports · Sep 18, 2025Peer-reviewedNeuroscience