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Spatially Resolved in vivo CRISPR Screen Sequencing via Perturb-DBiT
Alev Baysoy, Xiaolong Tian, Feifei Zhang…·Rong Fan
Perturb-DBiT co-sequences spatial transcriptomes and gRNAs on one tissue section, supporting genome-wide in vivo CRISPR screens in FFPE and fresh-frozen tumors across three cancer models.