Tumor cell-specific loss of GPX4 reprograms triacylglycerol metabolism to escape ferroptosis and impair antitumor immunity in NSCLC
Peng Wang, Shengdan Zhang, Xin Chen, Xu-Dong Yang, Shi Huang, Huiyong Yin, Hao-Yu Duan, Fuling Zhou, Jia Yu, Bo Zhong, Dandan Lin
This study shows that GPX4 loss in tumor cells promotes NSCLC by reprogramming lipid metabolism and suppressing antitumor immunity through ferroptosis evasion and immunoinhibitory TME.
Protein & Cell · Nov 19, 2025Peer-reviewedCell Biology