Author

Shi Yan

Simula Metropolitan Center for Digital Engineering

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Systems Biology· 2 Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Research Focus:dimensionality reduction· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Age K. SmildeiD· 2 shared Bo ChawesiD· 2 shared David A. HorneriD· 2 shared Evrim AcariD· 2 shared Morten Arendt RasmusseniD· 2 shared Aihui Tang· 1 shared Barbara M. BakkeriD· 1 shared Bing Liu· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersSystems Biology

Age K. SmildeORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

DEPICT enables sample-centric therapeutic prioritization across evolving and spatially heterogeneous tumor states

Shiwen Ma, Shi Yan, Xiaohu Wen, Chenxi Yu, Honghao Ma, Wenzhong Teng, Xuantong Zhou, Jingxi Gao, Siyun Wang, Mingxuan Li, Yanyi Huang, Han Kui, Nan Wu, Bing Liu, Chunhong Zheng

DEPICT prioritizes therapies within tumor contexts using deep learning, showing effectiveness across different tumor states and spatial heterogeneity.

bioRxiv · Oct 9, 2026 · PreprintBioinformatics

(2R,6R)-Hydroxynorketamine elicits rapid antidepressant effects by promoting astrocytic μ-δ opioid receptor heterodimerization

Yanxia Liang, Lingjun Wang, Yajie Li, Xiaoxue Li, Y Sun, Mengli Yang, Xuzhuo Guo, Junxu Mu, Chang Xu, Rupak Thapa, Ye Cheng, Huiqiang Zhang, Zecong He, Shi Yan, S M Yang, , Xiang Cai

This study identifies HNK's mechanism of action through astrocytic μ-δ opioid receptor heterodimerization, showing it restores these heterodimers and produces rapid antidepressant effects.

bioRxiv · Jun 3, 2026 · PreprintNeuroscience

Characterizing human postprandial metabolic response using multiway data analysis

Shi Yan, Lu Li, David A. Horner, Parvaneh Ebrahimi, Bo Chawes, Lars Ove Dragsted, Morten Arendt Rasmussen, Age K. Smilde, Evrim Acar

This study uses multiway data analysis to characterize postprandial metabolic responses in humans, revealing BMI-related differences in metabolite groups and temporal profiles between males.

Metabolomics · May 9, 2024Peer-reviewedSystems Biology

Analyzing postprandial metabolomics data using multiway models: A simulation study

Lu Li, Shi Yan, Barbara M. Bakker, Huub C. J. Hoefsloot, Bo Chawes, David A. Horner, Morten Arendt Rasmussen, Age K. Smilde, Evrim Acar

This study evaluates CP models for analyzing postprandial metabolomics data through simulations, showing their effectiveness in revealing metabolic patterns and group differences.

bioRxiv · Dec 19, 2022 · PreprintSystems Biology