DEPICT prioritizes therapies within tumor contexts using deep learning, showing effectiveness across different tumor states and spatial heterogeneity.

bioRxiv · Oct 9, 2026 · PreprintBioinformatics

High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes

Tianyi Chang, Shihui Zhao, Kunyue Deng, Zhizhao Liao, Mingchuan Tang, Yanxi Zhu, Wuji Han, Chenxi Yu, Wenyi Fan, Mengcheng Jiang, Guanbo Wang, Dongfang Liu, Jirun Peng, Yuhong Pang, Peng Fei, , Yanyi Huang

This paper introduces PRISM, a method for high-plex spatial RNA imaging using color intensity barcodes, validated across multiple tissues and showing the role of CAFs in tumor microenvironments.

Nature Biotechnology · Oct 30, 2025Peer-reviewedBioengineering

Variants in the SOX9 transactivation middle domain induce axial skeleton dysplasia and scoliosis

Lianlei Wang, Zhaoyang Liu, Sen Zhao, Kexin Xu, Valeria Aceves, Cheng Qiu, Hong Colleen Feng, Fangzhou Bian, Jingyu He, Christina J. Song, Benjamin Troutwine, Lian Liu, Samuel Ma, Yuchen Niu, Shengru Wang, , Jiashen Shao

The paper identifies a novel SOX9 variant in the TAM domain linked to axial skeletal dysplasia and scoliosis, showing reduced protein stability and recapitulating human phenotypes in mice.

Proceedings of the National Academy of Sciences · Jan 24, 2025Peer-reviewedGenetic & Genomic Medicine