Intestinal fructose metabolism triggers a GLP-1-β-cell axis to prevent post-fructose hyperglycaemia
Naoya Murao, Yusuke Seino, Risa Morikawa, Shihomi Hidaka, Takuya Haraguchi, Eisuke Tomatsu, Mutsumi Habara, Tamio Ohno, Norihide Yokoi, Norio Harada, Yoshitaka Hayashi, Yuichiro Yamada, Atsushi Suzuki
This study shows that intestinal fructose metabolism increases GLP-1 secretion, which enhances insulin release and prevents hyperglycaemia, with this effect being impaired in obese diabetic mice.
bioRxiv · Apr 1, 2025 · PreprintPhysiology