Naoya Murao

This study shows that intestinal fructose metabolism increases GLP-1 secretion, which enhances insulin release and prevents hyperglycaemia, with this effect being impaired in obese diabetic mice.

This study identifies pyruvate kinase as a key regulator linking β-cell fructose metabolism and insulin secretion, showing that a PK activator can restore fructose-stimulated insulin secretion in diabetic models.

This study shows sildenafil enhances insulin secretion in pancreatic β cells by increasing calcium influx, independent of L-type Ca2+ channels and PDE5.