Norihide Yokoi

Intestinal fructose metabolism triggers a GLP-1-β-cell axis to prevent post-fructose hyperglycaemia

This study shows that intestinal fructose metabolism increases GLP-1 secretion, which enhances insulin release and prevents hyperglycaemia, with this effect being impaired in obese diabetic mice.

Pyruvate kinase modulates the link between β-cell fructose metabolism and insulin secretion

This study identifies pyruvate kinase as a key regulator linking β-cell fructose metabolism and insulin secretion, showing that a PK activator can restore fructose-stimulated insulin secretion in diabetic models.

Comparative transcriptome and variant analyses of the pancreatic islets of a rat model of obese type 2 diabetes identifies a frequently distributed nonsense mutation in the lipocalin 2 gene

The paper identifies a nonsense mutation in the Lcn2 gene in a rat model of T2D but finds it does not significantly associate with T2D onset.