TLR-mediated activation of synovial fibroblasts from osteoarthritis patients promotes chondrocyte dysfunction
Yujie Dai, Ao Gong, Nayar Durán-Hernández, Xu Liang, Xiaohui Liu, Linden J. Gearing, Pawel Durek, Yonghai Li, Stephan Oehme, Peihua Wu, Frederik Heinrich, Katrin Lehmann, Shilei Wu, Luis Lauterbach, Lorenz Pichler, , Ping Shen
This study shows that TLR activation in OA synovial fibroblasts leads to inflammatory responses and chondrocyte dysfunction.
bioRxiv · Sep 8, 2026 · PreprintImmunology