Linden J. Gearing

This study shows that TLR activation in OA synovial fibroblasts leads to inflammatory responses and chondrocyte dysfunction.

This study identifies Annexin A2 as a critical mediator of RIG-I-like receptor responses to viral infection by promoting MDA5 oligomerization and enhancing interferon production.

This study shows that combining ASO targeting CD49d with PMO exon skipping improves muscle function and modulates gene expression in mdx mice, supporting ATL1102 combination therapy for DMD.

This study compares proliferation and tolerance in tissue-resident and recruited macrophages using single-cell RNA sequencing, finding that proliferative capacity differs between cell types.

CiiiDER predicts and analyses transcription factor binding sites using experimentally verified motifs, offering enrichment analysis to identify regulatory pathways.

This study characterizes IFNε expression, hormone regulation, and immune function in the human female reproductive tract.