Systematic Discovery of Phage Genes that Inactivate Bacterial Immune Systems
Shinjiro Ojima, Aa Haeruman Azam, Kohei Kondo, Wenhan Nie, Sai Wang, Kotaro Chihara, Azumi Tamura, Wakana Yamashita, Tomohiro Nakamura, Yo Sugawara, Motoyuki Sugai, Bo Zhu, Yoshimasa Takahashi, Koichi Watashi, Kotaro Kiga
This study identifies phage genes that inactivate bacterial immune systems by testing gene deletions in a phage library against bacterial defense systems.
bioRxiv · Apr 14, 2024 · PreprintMicrobiology