Kotaro Chihara

This study reveals the structural mechanism of the type IX Retron-Kva2 anti-phage defense system in Klebsiella variicola, showing how it cleaves host RNAs to inhibit phage infection.

The paper identifies Evangelion, a new family of anti-phage defence systems encoded in antimicrobial-resistance plasmids, through phenotype-guided analysis of a Staphylococcus aureus plasmid.

This study identifies phage genes that inactivate bacterial immune systems by testing gene deletions in a phage library against bacterial defense systems.

The paper introduces SEC-seq, a method for profiling RNA-protein complexes in E. coli using size exclusion chromatography, showing higher resolution than Grad-seq for smaller complexes.

This paper uses Grad-seq to identify RNA-protein complexes in Pseudomonas aeruginosa under standard and bacteriophage infection conditions, revealing new insights into RNA regulation and phage-host interactions.