A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment
Kenneth K.H. Ng, Mary A. Yui, Arnav Mehta, Sharmayne Siu, Blythe Irwin, Shirley Pease, Satoshi Hirose, Michael B. Elowitz, Ellen V. Rothenberg, Hao Yuan Kueh
The paper shows that stochastic cis-acting events at the Bcl11b locus control T-cell lineage commitment dynamics through a delay in gene activation.
eLife · Nov 12, 2018Peer-reviewedBioinformatics