Ellen V. Rothenberg

Bcl11b dose-dependently regulates positive selection of CD8 T cells to the virtual memory fate

This study shows that reduced Bcl11b dosage biases CD8 T cells toward the virtual memory fate during positive selection, independent of cytokine pathways.

T cell development from expanded hematopoietic progenitors reveals progression control by Lmo2, Erg, Spi1, Hoxa9, and Meis1

The paper expands hematopoietic progenitors to study T cell development, identifying key regulators that control progression.

T-cell commitment inheritance - an agent-based multi-scale model

The paper develops an agent-based model to study T-cell commitment timing and inheritance, showing a three-step process with transcriptional preparation, loss of Bcl11b-opposing function, and DN2b state transition.

Multiplex, quantitative, high-resolution imaging of protein:protein complexes via hybridization chain reaction

This paper develops a method to image protein:protein complexes with high resolution and quantitation using hybridization chain reaction, demonstrating its effectiveness in various biological samples.

Multi-scale dynamical modelling of T-cell development from an early thymic progenitor state to lineage commitment

The paper develops a multi-scale dynamic model of T-cell development, incorporating gene regulatory networks, epigenetic gates, and proliferation kinetics to simulate commitment dynamics.

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

The paper shows that stochastic cis-acting events at the Bcl11b locus control T-cell lineage commitment dynamics through a delay in gene activation.