Author

Mary A. Yui

California Institute of TechnologyORCID 0000-0002-3136-2181Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Ellen V. RothenbergiD· 2 shared Arnav MehtaiD· 1 shared Blythe IrwiniD· 1 shared Carsten PetersoniD· 1 shared Emil AnderssoniD· 1 shared Hao Yuan KuehiD· 1 shared Julia DeichmanniD· 1 shared Kenneth K.H. NgiD· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersSystems Biology

Ellen V. RothenbergORCID

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2 papers

Recent·Most cited

Multi-scale dynamical modelling of T-cell development from an early thymic progenitor state to lineage commitment

Victor Olariu, Mary A. Yui, Pawel Krupinski, Wen Zhou, Julia Deichmann, Emil Andersson, Ellen V. Rothenberg, Carsten Peterson

The paper develops a multi-scale dynamic model of T-cell development, incorporating gene regulatory networks, epigenetic gates, and proliferation kinetics to simulate commitment dynamics.

Cell Reports · Jan 1, 2021Peer-reviewedSystems Biology

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

Kenneth K.H. Ng, Mary A. Yui, Arnav Mehta, Sharmayne Siu, Blythe Irwin, Shirley Pease, Satoshi Hirose, Michael B. Elowitz, Ellen V. Rothenberg, Hao Yuan Kueh

The paper shows that stochastic cis-acting events at the Bcl11b locus control T-cell lineage commitment dynamics through a delay in gene activation.

eLife · Nov 12, 2018Peer-reviewedBioinformatics