Monitoring the poroelastic response of collagen gels with embedded senescent fibroblasts reveals tissue softening associated with collagen network reorganization
Jean Cacheux, Thomas Quénan, Daniel Alcaide, José Ordoñez-Miranda, Laurent Jalabert, Shizuka Nakano, Makoto Nakanishi, Pierre Cordelier, Aurélien Bancaud, Yukiko T. Matsunaga
This study uses a microfluidic model to show that senescent fibroblasts cause ECM softening through collagen network reorganization without changing permeability.
Physical Review Applied · Oct 24, 2025Peer-reviewedBiophysics