Dentate Neurogenesis Modulates Dorsal Hippocampal Excitation/Inhibition Balance Crucial for Cognitive Flexibility
Haowei Li, Risako Tamura, Daiki Hayashi, Hirotaka Asai, Junya Koga, Shota Ando, Sayumi Yokota, Jun Kaneko, Keisuke Sakurai, Akira Sumiyoshi, Tadashi S. Yamamoto, Keigo Hikishima, Kazumasa Z. Tanaka, Thomas John McHugh, Tatsuhiro Hisatsune
This study shows that silencing newborn neurons in the dentate gyrus disrupts the excitation/inhibition balance in the dorsal hippocampus, impairing cognitive flexibility in mice.
bioRxiv · Feb 22, 2023 · PreprintNeuroscience