Tadashi S. Yamamoto

Cnot4 heterozygosity attenuates high fat diet-induced obesity in mice and impairs PPARγ-mediated adipocyte differentiation.

This study shows that Cnot4 heterozygosity reduces obesity in mice on a high-fat diet by impairing PPARγ-mediated adipocyte differentiation without affecting metabolic gene expression or serum levels.

Post-transcriptional regulation by the CCR4-NOT deadenylase complex maintains redox homeostasis in insulin biosynthesis in mouse pancreatic β cells

The paper shows that CNOT7 deletion in mouse pancreatic β cells reduces insulin content and secretion by impairing proinsulin conversion, through reduced PRDX4 and increased CNOT8 binding to Prdx4 mRNA via MSI2.

Dentate Neurogenesis Modulates Dorsal Hippocampal Excitation/Inhibition Balance Crucial for Cognitive Flexibility

This study shows that silencing newborn neurons in the dentate gyrus disrupts the excitation/inhibition balance in the dorsal hippocampus, impairing cognitive flexibility in mice.

TOB is an effector of the hippocampus-mediated acute stress response

This study investigates the role of TOB in hippocampal stress response, showing increased TOB levels after acute stress and altered neural circuits and behavior in Tob-KO mice.

Synaptotagmin 2 is ectopically overexpressed in excitatory presynapses of a widely used CaMK2a-Cre mouse line

The paper identifies ectopic overexpression of synaptotagmin 2 in CamiCre mice, leading to functional phenotypes and highlighting issues with Cre driver line interpretation.

Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires Bicc1-Ccr4 RNA degradation complex

The paper investigates how fluid flow induces asymmetric Dand5 mRNA decay in the mouse embryo through the Bicc1-Ccr4 RNA degradation complex.

Loss of CNOT9 begets impairment in gastrulation leading to embryonic lethality

This study shows that loss of CNOT9 leads to embryonic lethality due to impaired gastrulation, with defects in Lefty2 mRNA decay and cytoplasmic interactions with miRNA-RISC.