Tatsuhiro Hisatsune

Impact of astrocytic C3-production on neuronal mitochondrial dysfunction in tauopathy mouse models

This study shows that astrocytic C3 production exacerbates neuronal mitochondrial dysfunction and necroptosis in tauopathy models, and that anserine can mitigate these effects.

Dentate Neurogenesis Modulates Dorsal Hippocampal Excitation/Inhibition Balance Crucial for Cognitive Flexibility

This study shows that silencing newborn neurons in the dentate gyrus disrupts the excitation/inhibition balance in the dorsal hippocampus, impairing cognitive flexibility in mice.