Thomas John McHugh

This study shows that neural network computations, not just anatomy, influence seizure susceptibility in brain regions.

This study identifies VGLUT2 reduction in VTAp-DCN axons as a mechanism linking chronic stress to depression-like behaviors through impaired dopamine signaling.

The paper identifies a stress-induced pain circuit involving locus coeruleus noradrenergic neurons and spinal astrocytes in mice, showing their role in mechanical pain hypersensitivity.

Acupuncture alleviates both motor and non-motor symptoms in Parkinson's disease by activating two distinct MCH projections.

The paper discusses findings on 40 Hz sensory stimulation's effects on the brain, supporting its potential benefits while noting technical limitations in amyloid burden studies.

This study identifies neural activity in the macaque medial posterior parietal cortex that reflects temporal context during encoding and retrieval of temporal-order memories.

The paper uses Hawkes process modeling to quantify cortical neuron firing patterns during sleep and wakefulness, finding that non-REM sleep increases firing intensity and shortens repetitive firing periods.

This study shows that silencing newborn neurons in the dentate gyrus disrupts the excitation/inhibition balance in the dorsal hippocampus, impairing cognitive flexibility in mice.

The paper shows that postsynaptic NMDA receptor-mediated K+ efflux reduces astrocytic glutamate uptake while enhancing presynaptic glutamate release.

This study shows that inhibiting CA2 neurons in mice reduces the temporal and informational precision of CA1 ensemble reactivation during sharp-wave ripples.

This study compares how acute and chronic stress affect spatial coding and gamma oscillations in the hippocampus of mice, finding that acute stress enhances spatial tuning while chronic stress impairs it.

This study identifies how hypothalamic SuM input modulates hippocampal CA2 circuitry, enhancing firing precision and influencing CA1 activity through synchronized inhibition.

This study shows that chronic stress reduces pyramidal cell activity in mice but increases neuronal synchrony during sharp-wave ripples, potentially affecting hippocampal function.

This study identifies hippocampal neuron subpopulations that encode delay and value information during delay-discounting decisions in mice.

The paper shows that conditional Ntng1 knockout in specific brain circuits affects mouse executive function traits like impulsivity and attention, but not overall EF, while complete knockout leads to EF deficits.

The paper investigates the role of Ntng gene paralogs in mouse executive function, showing differential expression in brain regions and task-dependent modulation of cognitive processes.