Discovery of D2469079A, A novel selective Toll-Like Receptor 7/8 Antagonist with Brain Penetrance
Xiaobing Deng, Xun Zhang, Wenjia Tian, Donghuai Xiao, Zhichao Du, Yanhong Wang, Shou Cao, Bo Li, Yan Hong Zhao, Huiling Chen, Yaning Su, Yijun Zhou
This paper identifies and characterizes D2469079A, a novel TLR7/8 antagonist with brain penetration, showing efficacy and safety in preclinical models.
bioRxiv · Apr 12, 2025 · PreprintImmunology