Author

Huiling Chen

ORCID 0000-0002-7714-9693Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

Bo LiiD· 2 shared Xiaobing Deng· 2 shared Donghuai Xiao· 1 shared Gang ZhouiD· 1 shared Shou Cao· 1 shared Weiping Lyv· 1 shared Wen‐Jia Tian· 1 shared Wenjia Tian· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPharmacology & Toxicology

Bo LiORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintOct 2, 2025

The Critical and Unexpected Role of a Methyl Group in Interleukin-17A Inhibitors

Xiaobing Deng, Bo Li, Huiling Chen…·Ye Zhou

The paper investigates the impact of a methyl group substitution in IL-17 inhibitors, finding that replacing a difluoro group with a methyl significantly improves safety and efficacy.

1 citation

humanexperimental assay

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ImmunologybioRxivPreprintApr 12, 2025

Discovery of D2469079A, A novel selective Toll-Like Receptor 7/8 Antagonist with Brain Penetrance

Xiaobing Deng, Xun Zhang, Wenjia Tian…·Yijun Zhou

This paper identifies and characterizes D2469079A, a novel TLR7/8 antagonist with brain penetration, showing efficacy and safety in preclinical models.

1 citation

humanmouse

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