Author

Xiaobing Deng

Peking UniversityPrimary ORCID profile (0009-0008-7998-2110 · 4 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Xiaobing DengiD4 papers · SUNY Upstate Medical University

Biology Disciplines

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Bioinformatics· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:database / resource· 1 Organism:mouse· 1 Assay:protein structure· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Bo LiiD· 2 shared Huiling CheniD· 2 shared Donghuai Xiao· 1 shared Gang ZhouiD· 1 shared Haoyu LiniD· 1 shared Jianfeng PeiiD· 1 shared Luhua LaiiD· 1 shared Shiwei WangiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersPharmacology & Toxicology

Bo LiORCID

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Author profile →

3 papers

Recent·Most cited

The Critical and Unexpected Role of a Methyl Group in Interleukin-17A Inhibitors

Xiaobing Deng, Bo Li, Huiling Chen, Gang Zhou, Weiping Lyv, Wen‐Jia Tian, Yuwen Su, Ye Zhou

The paper investigates the impact of a methyl group substitution in IL-17 inhibitors, finding that replacing a difluoro group with a methyl significantly improves safety and efficacy.

bioRxiv · Oct 2, 2025 · PreprintPharmacology & Toxicology

Discovery of D2469079A, A novel selective Toll-Like Receptor 7/8 Antagonist with Brain Penetrance

Xiaobing Deng, Xun Zhang, Wenjia Tian, Donghuai Xiao, Zhichao Du, Yanhong Wang, Shou Cao, Bo Li, Yan Hong Zhao, Huiling Chen, Yaning Su, Yijun Zhou

This paper identifies and characterizes D2469079A, a novel TLR7/8 antagonist with brain penetration, showing efficacy and safety in preclinical models.

bioRxiv · Apr 12, 2025 · PreprintImmunology

CavitySpace: A database of potential ligand binding sites in the human proteome

Shiwei Wang, Haoyu Lin, Zhixian Huang, Yufeng He, Xiaobing Deng, Youjun Xu, Jianfeng Pei, Luhua Lai

CavitySpace identifies potential ligand binding sites in the human proteome using predicted structures, aiding in drug design and function prediction.

Biomolecules · Jul 11, 2022Peer-reviewedBioinformatics