Author

Shuangyan Wan

Nanchang University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Jin ZhangiD· 2 shared Weiwei Nan· 2 shared Yaoguang Hua· 2 shared Bin HuiD· 1 shared Bing Q. SheniD· 1 shared Bing XiongiD· 1 shared Chen HuangiD· 1 shared Chenxin XiaoiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiophysics

Jin ZhangORCID

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Author profile →

2 papers

Recent·Most cited

Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating

Ling Zhong, Xiaoqing Lin, Xinyu Cheng, Shuangyan Wan, Yaoguang Hua, Weiwei Nan, Bin Hu, Xiangjun Peng, Zihan Zhou, Qiansen Zhang, Huaiyu Yang, Frank Noé, Zhenzhen Yan, Dexiang Jiang, Hangyu Zhang, , Panpan Hou

This study determines the structure of KCNQ1+KCNE1 in closed and open states, revealing structural transitions and dual PIP2 binding that regulate channel gating and IKs function.

Cell Research · Oct 2, 2025Peer-reviewedBiophysics

The Cryo-EM structure of TRPC1 and TRPC5 heterotetramer

Yixiang Chen, Tong Che, Xinyu Cheng, Xiaoqiang Yang, Ying Fu, Wei Yan Zhang, Sijia Lv, Tingting Yang, Qi Peng, Weiwei Nan, Shuangyan Wan, Yaoguang Hua, Juncheng Li, Xiaoyun Wu, Hu Han, , Jin Zhang

The paper reports the cryo-EM structure of TRPC1/5 heterotetramer, revealing structural features that differentiate it from TRPC5 homomers and provide insights into its functional properties.

bioRxiv · Nov 3, 2024 · PreprintBiophysics