This study identifies DNA methylation changes in aging and Alzheimer's disease using brain and blood data, finding concordant CpG sites associated with AD progression.

Genome Medicine · Jun 16, 2026Peer-reviewedGenetic & Genomic Medicine

Aggresomes protect mRNA under stress in Escherichia coli

Linsen Pei, Yujia Xian, Xiaodan Yan, Charley Schaefer, Aisha H. Syeda, Jamieson A. L. Howard, Wei Yan Zhang, Hebin Liao, Fan Bai, Mark C. Leake, Yingying Pu

The paper shows that aggresomes in E. coli store mRNA under stress, aiding rapid recovery by protecting mRNA from degradation and facilitating translation reactivation.

Nature Microbiology · Aug 19, 2025Peer-reviewedBiophysics

The Aging Epigenome: Integrative Analyses Reveal Functional Overlap with Alzheimer's Disease

Wei Yan Zhang, David Lukacsovich, Juan I. Young, Lissette Gomez, Michael A. Schmidt, Brian W. Kunkle, Xi Chen, Eden R. Martin, Lily Wang

This study identifies age-associated DNA methylation changes in blood and their overlap with Alzheimer's disease by analyzing two cohorts and finding shared genetic variants and CpGs associated with both aging and AD.

medRxiv · Jun 8, 2025 · PreprintGenetic & Genomic Medicine

The Cryo-EM structure of TRPC1 and TRPC5 heterotetramer

Yixiang Chen, Tong Che, Xinyu Cheng, Xiaoqiang Yang, Ying Fu, Wei Yan Zhang, Sijia Lv, Tingting Yang, Qi Peng, Weiwei Nan, Shuangyan Wan, Yaoguang Hua, Juncheng Li, Xiaoyun Wu, Hu Han, , Jin Zhang

The paper reports the cryo-EM structure of TRPC1/5 heterotetramer, revealing structural features that differentiate it from TRPC5 homomers and provide insights into its functional properties.

bioRxiv · Nov 3, 2024 · PreprintBiophysics