Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating
Ling Zhong, Xiaoqing Lin, Xinyu Cheng, Shuangyan Wan, Yaoguang Hua, Weiwei Nan, Bin Hu, Xiangjun Peng, Zihan Zhou, Qiansen Zhang, Huaiyu Yang, Frank Noé, Zhenzhen Yan, Dexiang Jiang, Hangyu Zhang, , Panpan Hou
This study determines the structure of KCNQ1+KCNE1 in closed and open states, revealing structural transitions and dual PIP2 binding that regulate channel gating and IKs function.
Cell Research · Oct 2, 2025Peer-reviewedBiophysics