Leukemic Stem Cell Subtypes Drive Distinct Niche Remodeling in Acute Myeloid Leukemia
Karin D. Prummel, Anna Mathioudaki, Ivan Berest, Shubhankar Sood, Jonas Rauchhaus, Thorsten Richter, Yagmur Baskan, Jonas Rauchaus, Clarissa Holitsch, Aryan Kamal, Juan P P Jauregui-Lozano, Dirk Hart, Rim Moussa, Robert Reinhardt, Swati Garg, , Judith B. Zaugg
This study identifies a specific leukemic stem cell (LSC) subtype that drives niche remodeling in AML by altering fibroblast states and suppressing osteolineage differentiation.
bioRxiv · Aug 25, 2026 · PreprintMolecular Biology