Juan P P Jauregui-Lozano

The paper shows that replication stress from chemotherapy accelerates erythroid differentiation but blocks terminal maturation, leading to impaired red cell output.

This study identifies a specific leukemic stem cell (LSC) subtype that drives niche remodeling in AML by altering fibroblast states and suppressing osteolineage differentiation.

This study shows that PBRM1 in PBAF is essential for EMT and metastasis in breast cancer by enabling promoter targeting and DNA accessibility for TGFβ1-inducible genes.

The paper investigates how active histone methylation marks, specifically H3K4me3 and H3K36me3, change with age in Drosophila photoreceptors and their impact on splicing and visual function.

This study identifies Clock and cycle as neuroprotective circadian regulators in Drosophila photoreceptors that prevent retinal degeneration and oxidative stress during aging.

This study shows that R-loop accumulation in aging Drosophila photoreceptor neurons correlates with gene expression loss and visual function decline, and that Top3β and RNase H1 can mitigate these effects.

The paper develops a method to profile chromatin states in specific Drosophila cell types using GFP-tagged nuclei and applies it to photoreceptor neurons.