Claudia Waskow

This study identifies a specific leukemic stem cell (LSC) subtype that drives niche remodeling in AML by altering fibroblast states and suppressing osteolineage differentiation.

This study uses a cross-species bone marrow niche model to show that plasticity in the murine niche supports human HSC engraftment, highlighting its role in stem cell function.

This study shows that MLL1 is essential for intestinal stem cell maintenance and regulates the expression of JAML, a cell adhesion molecule critical for stem cell niche interactions.

The paper uses RNAi screens in isogenic human stem cells to identify SMARCA4 as a differential regulator of stemness and differentiation in hematopoietic and neural stem cells.

The paper shows that human hematopoietic cells maintain normal epigenetic development patterns when transplanted into mice, and epigenetic aging does not accelerate in the xenogeneic environment.