Karin D. Prummel

The paper shows that replication stress from chemotherapy accelerates erythroid differentiation but blocks terminal maturation, leading to impaired red cell output.

This study identifies a specific leukemic stem cell (LSC) subtype that drives niche remodeling in AML by altering fibroblast states and suppressing osteolineage differentiation.

SpliceUp detects SF3B1-mutant cells in scRNA-seq data by analyzing aberrant splicing signatures, improving detection from low-coverage datasets.

This study investigates ZIC2's role in neural development, showing it acts as a pioneer transcription factor during pluripotency exit and an enhancer activator during neural induction.

This study reconstructs the mesodermal origins of neck muscles in vertebrates, showing that neck evolution arose from pre-existing muscle groups in fishes through developmental expansion.

This paper introduces SUM-seq, a scalable multiomic method for single-cell chromatin and RNA sequencing, revealing gene regulatory dynamics in macrophage polarization linked to autoimmune diseases.

This study identifies Hand2 as a key regulator of mesothelium progenitors in zebrafish and shows its reactivation in mesothelioma, linking developmental processes to disease.

The paper identifies a conserved regulatory program driving lateral plate mesoderm emergence across chordates using zebrafish and comparative analysis.

This study tracks zebrafish heart development and shows that the ventricle forms continuously from progenitor cells, with FGF signaling playing a critical role in this process.