Author

Shuhong Sun

Scripps Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:machine learning (classical)· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:protein sequence· 1 Assay:protein structure· 1

Frequent Co-Authors

Chao WangiD· 2 shared Pei ZhaoiD· 2 shared William E. BalchiD· 2 shared Darren M. Hutt· 1 shared Hao ShaoiD· 1 shared Jason E. GestwickiiD· 1 shared Samantha M. Scott· 1 shared Xi WangiD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 24 mutual co-author links

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2 shared papersMolecular Biology

Chao WangORCID

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2 papers

Recent·Most cited

Profiling Genetic Diversity Reveals the Molecular Basis for Balancing Function with Misfolding in Alpha-1 Antitrypsin

Chao Wang, Pei Zhao, Shuhong Sun, Xi Wang, William E. Balch

The paper uses a machine learning approach to analyze AAT variants and identifies critical residue interactions that balance function and misfolding, providing insights for therapeutic development.

bioRxiv · Mar 4, 2022 · PreprintMolecular Biology

Managing the Spatial Covariance of Genetic Diversity in Niemann-Pick C1 Through Modulation of the Hsp70 Chaperone System

Chao Wang, Samantha M. Scott, Shuhong Sun, Pei Zhao, Darren M. Hutt, Hao Shao, Jason E. Gestwicki, William E. Balch

The paper shows that modulating the Hsp70 chaperone system improves NPC1 protein trafficking and stability across diverse genotypes by altering spatial covariance tolerance.

Human Molecular Genetics · Sep 4, 2019Peer-reviewedGenomics