Author

Hao Shao

University of California, San FranciscoORCID 0000-0003-4437-5536Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Jason E. GestwickiiD· 2 shared Chao WangiD· 1 shared Darren M. Hutt· 1 shared Federica GuarraiD· 1 shared Giorgio ColomboiD· 1 shared Luca TorielliiD· 1 shared Pei ZhaoiD· 1 shared Samantha M. Scott· 1 shared

Activity by Year

2019-2025 · peak 1/yr

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10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Jason E. GestwickiORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedApr 3, 2025

How a pathogenic mutation impairs Hsp60 functional dynamics from monomeric to fully assembled states

Luca Torielli, Federica Guarra, Hao Shao…·Giorgio Colombo

This study uses molecular dynamics simulations to show that the V72I mutation in Hsp60 disrupts allosteric communication, rigidifying its complexes and impairing function.

15 citations

structural biologydeep learning

𝕏 PostBluesky

GenomicsHuman Molecular GeneticsPeer-reviewedSep 4, 2019

Managing the Spatial Covariance of Genetic Diversity in Niemann-Pick C1 Through Modulation of the Hsp70 Chaperone System

Chao Wang, Samantha M. Scott, Shuhong Sun…·William E. Balch

The paper shows that modulating the Hsp70 chaperone system improves NPC1 protein trafficking and stability across diverse genotypes by altering spatial covariance tolerance.

27 citations

humanprotein structure

𝕏 PostBluesky