This study determines the structure of the AP5:SPG11-SPG15 complex and shows it binds PI3P, senses membrane curvature, and drives membrane remodeling in vitro.

Nature Structural & Molecular Biology · Apr 2, 2025Peer-reviewedBiochemistry

Empirical estimates of the mutation rate for an alphabaculovirus

Dieke Boezen, Ghulam Ali, Manli Wang, Xi Wang, Wopke van der Werf, Just M. Vlak, Mark P. Zwart

The paper estimates the mutation rate of an alphabaculovirus using a stable genomic insert to avoid selection bias, finding a low mutation rate of 1x10-7 s/n/r.

PLoS Genetics · Jun 6, 2022Peer-reviewedGenetics

Profiling Genetic Diversity Reveals the Molecular Basis for Balancing Function with Misfolding in Alpha-1 Antitrypsin

Chao Wang, Pei Zhao, Shuhong Sun, Xi Wang, William E. Balch

The paper uses a machine learning approach to analyze AAT variants and identifies critical residue interactions that balance function and misfolding, providing insights for therapeutic development.

bioRxiv · Mar 4, 2022 · PreprintMolecular Biology

Constitutive signal bias mediated by the human GHRHR splice variant 1

Zhaotong Cong, Fulai Zhou, Chao Zhang, Xinyu Zou, Huibing Zhang, Yuzhe Wang, Qingtong Zhou, Xiaoqing Cai, Qiaofeng Liu, Jie Li, Lijun Shao, Chunyou Mao, Xi Wang, Jihong Wu, Tian Xia, , Ming‐Wei Wang

The paper identifies a splice variant of the GHRHR receptor that mediates constitutive signal bias towards β-arrestin recruitment, impacting downstream signaling pathways in prostate cancer cells.

Proceedings of the National Academy of Sciences · Oct 1, 2021Peer-reviewedMolecular Biology