Pei Zhao

This study identifies the conserved NUS-1/DHDDS complex in C. elegans as essential for linking N-glycosylation to lipid and lysosomal homeostasis, revealing its role in preventing developmental failure and metabolic disorders.

The paper functionally characterizes human genetic variants by creating and analyzing matching variants in C. elegans using CRISPR/Cas9.

The paper uses a machine learning approach to analyze AAT variants and identifies critical residue interactions that balance function and misfolding, providing insights for therapeutic development.

ConVarT matches human genetic variants with equivalent variants in mice and C. elegans to provide functional insights for human mutations.

The paper shows that modulating the Hsp70 chaperone system improves NPC1 protein trafficking and stability across diverse genotypes by altering spatial covariance tolerance.