Stalling of elongating Pol II triggers Ser7 phosphorylation in trans to drive transcription recovery
Iván Shlamovitz, Yu Bao, Tea Toteva, Alastair Crisp, Shutong Ye, Steven Wingett, Roberta Cacioppo, Anna Edmondson, Daniela Castiblanco, Michael A. Boemo, Ana Tufegdžić Vidaković
The paper identifies a third mechanism for resolving stalled RNA polymerase II by showing that transcription stalling triggers GSK3-mediated phosphorylation of Ser7 on Pol II, which primes incoming Pol II for efficient elongation.
bioRxiv · Dec 5, 2025 · PreprintMolecular Biology