Alastair Crisp

This study maps DNA supercoiling and chromatin interactions during human stem cell differentiation, showing that gene activation increases negative supercoiling and correlates with enhanced DNA contacts.

The paper introduces ORILINX, a genome language model that predicts replication origins in human and other mammalian genomes using sequence context.

The paper identifies a third mechanism for resolving stalled RNA polymerase II by showing that transcription stalling triggers GSK3-mediated phosphorylation of Ser7 on Pol II, which primes incoming Pol II for efficient elongation.

The paper identifies MALT1 as a key mediator of IL-17 signaling in C. elegans neurons, showing its role in behavior, immunity, and longevity.

The paper uses transcriptomics to show that pleuropodia in locust embryos express enzymes for cuticle degradation and immunity, supporting their role in hatching and immune defense.

The paper shows that PrimPol-mediated repriming limits R-loop formation during S phase, preventing replication blocks at susceptible sequences.