Ana Tufegdžić Vidaković

The paper shows that glucocorticoid receptor signaling resets circadian rhythms through post-transcriptional mechanisms, not transcriptional activation.

The paper shows that transcriptional stability is maintained through hierarchical buffering of RNA polymerase II pools under varying levels of depletion.

The paper identifies a third mechanism for resolving stalled RNA polymerase II by showing that transcription stalling triggers GSK3-mediated phosphorylation of Ser7 on Pol II, which primes incoming Pol II for efficient elongation.

This study identifies the structural basis of RECQL5-induced RNA polymerase II transcription braking and reveals its coordination with the TCR complex for reactivation.