Hepatic Yap1 activates systemic catabolism and muscle loss during organ repair: evidence for a liver-derived common mechanism with cancer cachexia.
Tewfik Hamidi, Yanlin Jiang, Tyler P. Robinson, Andris Kronbergs, Ernie D. Au, Joseph E. Rupert, Xiaoling Zhong, Siangsin Lal, Tiffany W. Liang, Alexander G. Robling, April M. Hoggatt, Robson Francisco Carvalho, Sarah Santiloni Cury, Clark D. Wells, Teresa A. Zimmers, Leonidas G. Koniaris
This study shows that liver-derived Yap1 activation during organ repair induces systemic catabolism and muscle loss, similar to cancer cachexia.
bioRxiv · Apr 1, 2025 · PreprintPhysiology