Conserved intrinsically disordered region of DNAJB6 dictates its surveillance of FG-Nup condensates
Tessa Bergsma, Maiara Kolbe Musskopf, Alejandro Feito, Paola Gallardo, Mathieu Edouard Rebeaud, E. F. Elsiena Kuiper, Nuria H. Espejo, Andrés R. Tejedor, Jarmo Feenstra, Sidath M.Y. Fernando, Anton Steen, Rifka Vlijm, Jorge R. Espinosa, Harm H. Kampinga, Liesbeth M. Veenhoff
The paper shows that DNAJB6's conserved intrinsically disordered region enables its surveillance of FG-Nup condensates by forming stable assemblies that outcompete FG-Nup interactions.
bioRxiv · Oct 20, 2025 · PreprintBiochemistry