Tessa Bergsma

This study identifies Jjj2 as a chaperone that regulates nucleoporin condensation in budding yeast, showing its role in maintaining NPC permeability and preventing aggregation.

The paper shows that DNAJB6's conserved intrinsically disordered region enables its surveillance of FG-Nup condensates by forming stable assemblies that outcompete FG-Nup interactions.

The paper introduces PhaseMetrics, an image analysis pipeline for quantifying biomolecular condensates in vitro and in cells, showing its accuracy across different experimental systems.

This study identifies DNAJB6 as a molecular chaperone that prevents FG-Nup aggregation during interphase nuclear pore complex biogenesis.