Liesbeth M. Veenhoff

Spatial control of karyopherin binding avidity within NPC mimics revealed by designer FG-Nucleoporins

This study designs and tests artificial FG-Nups to show that spacing and charge-to-hydrophobicity ratio affect Kap95 binding and transport selectivity through NPCs.

A tool to pulse-label yeast Nuclear Pore Complexes in imaging and biochemical experiments

The paper introduces a method to pulse-label yeast Nuclear Pore Complexes using a nanobody, enabling tracking in imaging and biochemical experiments.

The chaperone Jjj2 regulates nucleoporin condensation in budding yeast

This study identifies Jjj2 as a chaperone that regulates nucleoporin condensation in budding yeast, showing its role in maintaining NPC permeability and preventing aggregation.

The role of the nuclear pore complex in the stability of disease-related short tandem DNA repeats

This study shows disease-related short tandem repeats relocate to nuclear pore complexes, with implications for genome stability and repeat dynamics.

Conserved intrinsically disordered region of DNAJB6 dictates its surveillance of FG-Nup condensates

The paper shows that DNAJB6's conserved intrinsically disordered region enables its surveillance of FG-Nup condensates by forming stable assemblies that outcompete FG-Nup interactions.

Detecting Nuclear Pore Complex assembly in living cells

This paper introduces a nanobody-based method to detect newly forming nuclear pore complexes in yeast, revealing novel insights into their assembly and localization.

Imaging-Based Quantitative Assessment of Biomolecular Condensates in vitro and in Cells

The paper introduces PhaseMetrics, an image analysis pipeline for quantifying biomolecular condensates in vitro and in cells, showing its accuracy across different experimental systems.

Specificity and mechanism of 1,6 hexanediol-induced disruption of nuclear transport

This study investigates how 1,6-hexanediol disrupts nuclear pore complex permeability in yeast by displacing nuclear transport receptors without affecting NPC subunits or cell viability.

The molecular chaperone DNAJB6 provides surveillance of FG-Nups and is required for interphase nuclear pore complex biogenesis

This study identifies DNAJB6 as a molecular chaperone that prevents FG-Nup aggregation during interphase nuclear pore complex biogenesis.

A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells

The paper identifies genes that suppress spontaneous mutation accumulation in yeast cells, finding PEX19 as an age-specific mutation suppressor.