Maiara Kolbe Musskopf

The paper shows that DNAJB6's conserved intrinsically disordered region enables its surveillance of FG-Nup condensates by forming stable assemblies that outcompete FG-Nup interactions.

This study identifies DNAJB6 as a molecular chaperone that prevents FG-Nup aggregation during interphase nuclear pore complex biogenesis.

The paper shows that targeting ATM, ATR, or DNA topoisomerases causes widespread protein aggregation through chaperone system overload, similar to proteotoxic stress and proteinopathies.